101 research outputs found
Within-Subject Joint Independent Component Analysis of Simultaneous fMRI/ERP in an Auditory Oddball Paradigm
The integration of event-related potential (ERP) and functional magnetic resonance imaging (fMRI) can contribute to characterizing neural networks with high temporal and spatial resolution. This research aimed to determine the sensitivity and limitations of applying joint independent component analysis (jICA) within-subjects, for ERP and fMRI data collected simultaneously in a parametric auditory frequency oddball paradigm. In a group of 20 subjects, an increase in ERP peak amplitude ranging 1–8 μV in the time window of the P300 (350–700 ms), and a correlated increase in fMRI signal in a network of regions including the right superior temporal and supramarginal gyri, was observed with the increase in deviant frequency difference. JICA of the same ERP and fMRI group data revealed activity in a similar network, albeit with stronger amplitude and larger extent. In addition, activity in the left pre- and post-central gyri, likely associated with right hand somato-motor response, was observed only with the jICA approach. Within-subject, the jICA approach revealed significantly stronger and more extensive activity in the brain regions associated with the auditory P300 than the P300 linear regression analysis. The results suggest that with the incorporation of spatial and temporal information from both imaging modalities, jICA may be a more sensitive method for extracting common sources of activity between ERP and fMRI
Neural pathways for visual speech perception
This paper examines the questions, what levels of speech can be perceived visually, and how is visual speech represented by the brain? Review of the literature leads to the conclusions that every level of psycholinguistic speech structure (i.e., phonetic features, phonemes, syllables, words, and prosody) can be perceived visually, although individuals differ in their abilities to do so; and that there are visual modality-specific representations of speech qua speech in higher-level vision brain areas. That is, the visual system represents the modal patterns of visual speech. The suggestion that the auditory speech pathway receives and represents visual speech is examined in light of neuroimaging evidence on the auditory speech pathways. We outline the generally agreed-upon organization of the visual ventral and dorsal pathways and examine several types of visual processing that might be related to speech through those pathways, specifically, face and body, orthography, and sign language processing. In this context, we examine the visual speech processing literature, which reveals widespread diverse patterns activity in posterior temporal cortices in response to visual speech stimuli. We outline a model of the visual and auditory speech pathways and make several suggestions: (1) The visual perception of speech relies on visual pathway representations of speech qua speech. (2) A proposed site of these representations, the temporal visual speech area (TVSA) has been demonstrated in posterior temporal cortex, ventral and posterior to multisensory posterior superior temporal sulcus (pSTS). (3) Given that visual speech has dynamic and configural features, its representations in feedforward visual pathways are expected to integrate these features, possibly in TVSA
Method for Spatial Overlap Estimation of Electroencephalography and Functional Magnetic Resonance Imaging Responses
Background
Simultaneous functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) measurements may represent activity from partially divergent neural sources, but this factor is seldom modeled in fMRI-EEG data integration. New method
This paper proposes an approach to estimate the spatial overlap between sources of activity measured simultaneously with fMRI and EEG. Following the extraction of task-related activity, the key steps include, 1) distributed source reconstruction of the task-related ERP activity (ERP source model), 2) transformation of fMRI activity to the ERP spatial scale by forward modelling of the scalp potential field distribution and backward source reconstruction (fMRI source simulation), and 3) optimization of fMRI and ERP thresholds to maximize spatial overlap without a priori constraints of coupling (overlap calculation). Results
FMRI and ERP responses were recorded simultaneously in 15 subjects performing an auditory oddball task. A high degree of spatial overlap between sources of fMRI and ERP responses (in 9 or more of 15 subjects) was found specifically within temporoparietal areas associated with the task. Areas of non-overlap in fMRI and ERP sources were relatively small and inconsistent across subjects. Comparison with existing method
The ERP and fMRI sources estimated with solely jICA overlapped in just 4 of 15 subjects, and strictly in the parietal cortex. Conclusion
The study demonstrates that the new fMRI-ERP spatial overlap estimation method provides greater spatiotemporal detail of the cortical dynamics than solely jICA. As such, we propose that it is a superior method for the integration of fMRI and EEG to study brain function
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Differential rates of perinatal maturation of human primary and nonprimary auditory cortex
Abstract Primary and nonprimary cerebral cortex mature along different timescales; however, the differences between the rates of maturation of primary and nonprimary cortex are unclear. Cortical maturation can be measured through changes in tissue microstructure detectable by diffusion magnetic resonance imaging (MRI). In this study, diffusion tensor imaging (DTI) was used to characterize the maturation of Heschl’s gyrus (HG), which contains both primary auditory cortex (pAC) and nonprimary auditory cortex (nAC), in 90 preterm infants between 26 and 42 weeks postmenstrual age (PMA). The preterm infants were in different acoustical environments during their hospitalization: 46 in open ward beds and 44 in single rooms. A control group consisted of 15 term-born infants. Diffusion parameters revealed that (1) changes in cortical microstructure that accompany cortical maturation had largely already occurred in pAC by 28 weeks PMA, and (2) rapid changes were taking place in nAC between 26 and 42 weeks PMA. At term equivalent PMA, diffusion parameters for auditory cortex were different between preterm infants and term control infants, reflecting either delayed maturation or injury. No effect of room type was observed. For the preterm group, disturbed maturation of nonprimary (but not primary) auditory cortex was associated with poorer language performance at age two years
A Review of NEST Models, and Their Application to Improvement of Particle Identification in Liquid Xenon Experiments
Liquid xenon is a leader in rare-event physics searches. Accurate modeling of
charge and light production is key for simulating signals and backgrounds in
this medium. The signal- and background-production models in the Noble Element
Simulation Technique (NEST) are presented. NEST is a simulation toolkit based
on experimental data, fit using simple, empirical formulae for the average
charge and light yields and their variations. NEST also simulates the final
scintillation pulses and exhibits the correct energy resolution as a function
of the particle type, the energy, and the electric fields. After vetting of
NEST against raw data, with several specific examples pulled from XENON,
ZEPLIN, LUX/LZ, and PandaX, we interpolate and extrapolate its models to draw
new conclusions on the properties of future detectors (e.g., XLZD's), in terms
of the best possible discrimination of electron(ic) recoil backgrounds from a
potential nuclear recoil signal, especially WIMP dark matter. We discover that
the oft-quoted value of 99.5% discrimination is overly conservative,
demonstrating that another order of magnitude improvement (99.95%
discrimination) can be achieved with a high photon detection efficiency (g1 ~
15-20%) at reasonably achievable drift fields of 200-350 V/cm.Comment: 24 Pages, 6 Tables, 15 Figures, and 15 Equation
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Development of a nuclear test strategy for Test Program Element II
As part of Phase O in Test Program Element II of the Office of Fusion Energy's First Wall/Blanket/Shield Engineering Test Program, a test strategy has been developed to address the blanket/shield's (B/S's) thermal-hydraulic and thermomechanical data needs, which were identified in an earlier task through the use of nuclear and supporting nonnuclear testing. In Phase I, which extends through 1984, this strategy emphasizes the development of pre-design information and the nonnuclear supporting tests. After Phase I, nuclear testing will be emphasized, and B/S design-verification testing will become more important. The proposed program will investigate a solid-breeder-blanket concept via nuclear testing. This program can begin in Phase I with nonnuclear support tests, and can progress to integrated nuclear testing soon after the completion of Phase I. The program's approximate cost and schedule are presented. In addition, other possible areas of study for Phase I, and strategies for the use of nuclear and nonnuclear facilities after Phase I are outlined
Process simulations of post-combustion CO2 capture for coal and natural gas-fired power plants using a polyethyleneimine/silica adsorbent
The regeneration heat for a polyethyleneimine (PEI)/silica adsorbent based carbon capture system is first assessed in order to evaluate its effect on the efficiency penalty of a coal or natural gas power plant. Process simulations are then carried out on the net plant efficiencies for a specific supercritical 550 MWe pulverized coal (PC) and a 555 MWe natural gas combined cycle (NGCC) power plant integrated with a conceptually designed capture system using fluidized beds and PEI/silica adsorbent. A benchmark system applying an advanced MEA absorption technology in a NETL report (2010) is used as a reference system. Using the conservatively estimated parameters, the net plant efficiency of the PC and NGCC power plant with the proposed capture system is found to be 1.5% and 0.6% point higher than the reference PC and NGCC systems, respectively. Sensitivity analysis has revealed that the moisture adsorption, working capacity and heat recovery strategies are the most influential parameters to the power plant efficiency. Under an optimal scenario with improvements in increasing the working capacity by 2% points and decreasing moisture adsorption by 1% point, the plant efficiencies with the proposed capture system are 2.7% (PC) and 1.9% (NGCC) points higher than the reference systems
A Next-Generation Liquid Xenon Observatory for Dark Matter and Neutrino Physics
The nature of dark matter and properties of neutrinos are among the mostpressing issues in contemporary particle physics. The dual-phase xenontime-projection chamber is the leading technology to cover the availableparameter space for Weakly Interacting Massive Particles (WIMPs), whilefeaturing extensive sensitivity to many alternative dark matter candidates.These detectors can also study neutrinos through neutrinoless double-beta decayand through a variety of astrophysical sources. A next-generation xenon-baseddetector will therefore be a true multi-purpose observatory to significantlyadvance particle physics, nuclear physics, astrophysics, solar physics, andcosmology. This review article presents the science cases for such a detector.<br
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